Lenovo ThinkPad E16 Gen 4 - Ryzen AI 7 345 / 32 GB / 512 GB SSD / 16" WUXGA / Win 11 Pro / Negro

The Lenovo ThinkPad E16 Gen 4 (type 21Y4, model 21Y4006MGE) is a 16-inch business laptop engineered for professionals who demand strong multitasking performance, robust security and all-day productivity. It combines the AMD Ryzen AI 7 345 processor with 32 GB of DDR5 memory and a 512 GB PCIe 4.0 NVMe SSD, all framed by a spacious WUXGA display with a 16:10 aspect ratio and an anti-glare matte finish.

Advantages

The AMD Ryzen AI 7 345 (Krackan Point, 4 nm) delivers eight cores and sixteen threads with a boost clock of up to 4.9 GHz, paired with a dedicated XDNA 2 NPU rated at up to 50 TOPS for on-device AI acceleration in video calls, transcription and co-pilot features. Integrated AMD Radeon 860M graphics (RDNA 3.5) drive the crisp 16:10 WUXGA panel and external monitors via HDMI 2.1 or USB4 without a discrete GPU. With 32 GB DDR5-5600 across two SO-DIMM slots — user-upgradeable to 64 GB — the system glides through large spreadsheets, virtualisation and heavy browser workloads. The 400-nit anti-glare IPS panel and 16:10 format provide extra vertical space for documents and code. Security is covered by a fingerprint reader, TPM, webcam privacy shutter and Kensington lock slot, while Wi-Fi 7 and a wired Gigabit Ethernet port ensure reliable connectivity.

Suitable for

• Finance, engineering and administrative professionals running demanding productivity suites and browser-based applications
• Power users who keep many applications, browser tabs or light virtual machines open simultaneously
• Hybrid and remote workers who require clear 1080p video conferencing and a large 16-inch display
• Enterprise fleets needing a durable, serviceable ThinkPad with hardware security and both wired and wireless networking

Key specifications

• Brand: Lenovo
• Model: ThinkPad E16 Gen 4 (21Y4006MGE)
• EAN: 199276765703
• Processor: AMD Ryzen AI 7 345, 6 cores / 12 threads, up to 4.9 GHz boost, 24 MB total cache, XDNA 2 NPU (up to 50 TOPS)
• Graphics: Integrated AMD Radeon 860M (RDNA 3.5)
• Memory: 32 GB DDR5-5600 (2x SO-DIMM, upgradeable to 64 GB)
• Storage: 512 GB SSD, PCIe 4.0 NVMe
• Display: 16 inch WUXGA (1920 x 1200) IPS, 16:10, anti-glare, 400 nits
• Operating system: Windows 11 Pro (64-bit)
• Keyboard: Spill-resistant backlit keyboard with numeric keypad, German (QWERTZ) layout
• Camera: FHD 1080p webcam with privacy shutter
• Connectivity: Wi-Fi 7 (802.11be), Bluetooth 5.4, Gigabit Ethernet (RJ-45)
• Ports: 2x USB-C (USB4 40 Gbps), USB-A (5 Gbps), USB-A (10 Gbps), HDMI 2.1, RJ-45, headphone/microphone combo
• Security: Fingerprint reader, TPM, webcam privacy shutter, Kensington lock slot
• Battery: 64 Wh Li-Ion, 65 W USB-C adapter
• Colour: Black
• Weight: 1.81 kg

How to use

Power on, complete Windows 11 Pro setup and enrol your fingerprint in Windows Hello for fast, password-free sign-in. Connect over Wi-Fi 7 or the built-in Gigabit Ethernet port, then attach a docking station, external displays or fast storage via the USB4 USB-C port — which also charges the laptop with the included 65 W adapter.

Recommendations

This configuration ships with a German (QWERTZ) keyboard layout and a German-localised Windows 11 Pro image. For business deployments, enable BitLocker encryption, keep the webcam privacy shutter closed when not in use, and use a USB4 dock to drive multiple external monitors from a single cable. The two SO-DIMM slots make it straightforward to expand memory to 64 GB later.